Osteoarthritis is the most common joint disorder with symptoms in the hands, knees, hips, back, and neck. It is unclear exactly how excess weight influences OA. Clearly, being overweight increases the load placed on the joints such as the knee, which increases stress and could possibly hasten the breakdown of cartilage. For example, it is estimated that a force of nearly three to six times one’s body weight is exerted across the knee while walking; an increase in body weight increases the force by this amount. However, overweight has also been associated with higher rates of hand OA in some studies suggesting the involvement of a circulating systemic factor as well.